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Home > Polymer-Peptide Conjugate Hydrogels; Towards Controlled Drug Delivery
 
Polymer-Peptide Conjugate Hydrogels; Towards Controlled Drug Delivery
Paper Type
Contributed Paper
Title
Polymer-Peptide Conjugate Hydrogels; Towards Controlled Drug Delivery
Author
Arun A. Sohdi, Darren Campbell andPaul D. Topham*
Email
p.d.topham@aston.ac.uk
Abstract:

Peptide-based materials exhibit remarkable supramolecular self-assembling behavior, owing to their overwhelming propensity to from hierarchical structures from α-helices and β-sheets. Coupling a peptide sequence to a synthetic polymer chain allows greater control over the final physical properties of the supermolecular material. So-called ‘polymer-peptide conjugates’ can be used to create biocompatible hydrogels which are held together by reversible physical interactions. Potentially, the hydrogels can be loaded with aqueous-based drug molecules, which can be injected into targeted sites in the body if they can exhibit a gel-sol-gel transition under application and removal of a shear force. In this review, we introduce this topic to readers new to the field of polymer-peptide conjugates, discussing common synthetic strategies and their self-assembling behavior. The lack of examples of actual drug delivery applications from polymer-peptide conjugates is highlighted in an attempt to incite progress in this area.

Start & End Page
351 - 372
Received Date
2012-03-16
Accepted Date
2012-04-21
Full Text
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Keyword:
Keyword
polymer-peptide conjugates, hydrogels, drug delivery,
Volume
Vol.39 No.3 (JULY 2012)